Nanowires for Biosensing
The fast development of point-of-care diagnostics and personalized medicine raises new requirements to future biosensors in terms of limit of detection, throughput, materials and miniaturization. Within this framework we are currently involved in developing two parallel sensor architectures implemented as either ion-sensitive field-effect transistors (ISFETs) or extended-gate field-effect transistors (EGFETs). These devices are aimed at facilitating real-time measurements of various metal ions, pH and proteins in complex fluids. Our expertise ranges from surface functionalization with highly specific groups and molecules, to micro- and nanofabrication, microfluidics as well as electrochemistry and the interfacial double layer. The central focus of this research activity is to demonstrate the operation of these sensors in arrays of multiple sensing units for multiplexed sensing applications.